The Global Need for New Antimicrobial and Antibiofilm Agents

Data scadenza invio manoscritto 31/12/2021
Nome rivista ANTIBIOTICS
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Impact factor della rivista 3.893
Guest Editor socio SIMGBM e eventuali Co-editors Domenico Schillaci, Laboratory of Microbiology, Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, 90123 Palermo, Italy
Titolo della Special Issue "The Global Need for New Antimicrobial and Antibiofilm Agents"
Breve descrizione della Special issue (max 200 caratteri in inglese) Modern medicine and even the structure of society are established on the ability to control infectious diseases. Antibiotics and vaccines represent the two fundamental pillars on which the ability to manage and fight pathogens is based. However, one of the two pillars falters due to antimicrobial resistance (AMR). Bacterial resistance may develop at cellular level (mutations or horizontal gene transfer) and sessile community, based on adaptive resistance and tolerance involving shift from free-living cells to a biofilm community. It is estimated that, in clinical settings, at least 60% of infections are due to biofilms, which are often the cause of polymicrobial and chronic infections. Moreover, in many cases, antimicrobials used in agriculture and animal breeding are equal to the ones used in clinical settings, increasing the risk of the rise and spread of resistant bacteria, including common pathogens for both animals and humans. Reducing antibiotic usage in farms and replacing it with new molecules could be a short-term approach to facing AMR.

New antimicrobials that are able to hit resistant pathogens and biofilm are strongly needed. It is time for action in order to address antibiotic-resistant strains, especially carbapenem-resistant Enterobacteriaceae (CRE), Acinetobacter baumannii (CRAB) and Pseudomonas aeruginosa (CRPA), which are resistant to last-resort antibiotics.

This Special Issue is aimed at researchers who focus their scientific interest on drug discovery strategies to develop new molecules with antimicrobial action and antibiofilm. Potential topics may include but are not limited to antimicrobial peptides of various organisms, natural substances, nanoparticles of microbial origin, and small synthetic organic molecules. Topics such as strategies aimed at improving the efficiency of conventional antibiotics through nano/micro-release and micro-release systems with functionalized polymers are also welcome.
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